Proton Pump Inhibitors updated on 08-09-2023

Very low birth weight (< 1500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4446
R10576		 Matok, 2012 Very low birth weight (< 1500 g) 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.17 [0.03;1.82] 1/666   1,393/108,878 1,394 666
ref
Total 1 studies 0.17 [0.02;1.32] 1,394 666
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Matok, 2012Matok, 2012 0.17[0.03; 1.82]1,3946660%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.17[0.02; 1.32]1,394666 -NAMatok, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.17[0.02; 1.32]1,394666 -NAMatok, 2012 1 Tags Adjustment   - Yes  - Yes 0.17[0.02; 1.32]1,394666 -NAMatok, 2012 1 All studiesAll studies 0.17[0.02; 1.32]1,394666 -NAMatok, 2012 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.17[0.02; 1.32]1,394666 -NAMatok, 2012 10.510.01.0