Omeprazole

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4802
R12325		 Lind, 2013 Isolated Second- or Third-Degree Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 2.90 [0.70;11.30] 5/10   1,532/5,841 1,537 10
ref
Total 1 studies 2.90 [0.72;11.65] 1,537 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lind, 2013Lind, 2013 2.90[0.70; 11.30]1,537100%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.90[0.72; 11.65]1,53710 -NALind, 2013 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.90[0.72; 11.65]1,53710 -NALind, 2013 1 Tags Adjustment   - Yes  - Yes 2.90[0.72; 11.65]1,53710 -NALind, 2013 1 All studiesAll studies 2.90[0.72; 11.65]1,53710 -NALind, 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.86[0.93; 3.72]1,5381,9490%NALind, 2013 Pasternak, 2010 Ruigomez (Controls unexposed NOS), 1999 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.46[0.05; 4.16]34010%NARuigomez (Controls exposed to other treatment, sick), 1999 Källèn (Controls exposed to other treatment, sick), 1998 20.510.01.0