Omeprazole

Bilateral renal agenesis including Potter syndrome

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4878
R12805		 Ruigomez (Controls exposed to other treatment, sick), 1999 Potter's syndrome (bilateral renal agenesia) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 4.09 [0.08;207.06] C
excluded (control group) 		0/139   0/567 0 139
ref
S4877
R12758		 Ruigomez (Controls unexposed NOS), 1999 Potter's syndrome (bilateral renal agenesia) 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 3.79 [0.15;93.41] C 0/139   1/1,575 1 139
ref
Total 1 studies 3.79 [0.15;93.41] 1 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ruigomez (Controls unexposed NOS), 1999Ruigomez, 1999 1 3.79[0.15; 93.41]11390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.79[0.15; 93.41]1139 -NARuigomez (Controls unexposed NOS), 1999 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.79[0.15; 93.41]1139 -NARuigomez (Controls unexposed NOS), 1999 1 Tags Adjustment   - No  - No 3.79[0.15; 93.41]1139 -NARuigomez (Controls unexposed NOS), 1999 1 All studiesAll studies 3.79[0.15; 93.41]1139 -NARuigomez (Controls unexposed NOS), 1999 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4878

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.79[0.15; 93.41]1139 -NARuigomez (Controls unexposed NOS), 1999 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.09[0.08; 207.06]-139 -NARuigomez (Controls exposed to other treatment, sick), 1999 10.510.01.0