Esomeprazole

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8549
R28420		 Cluver, 2018 Significant changes in fetal heart rate pattern necessitating delivery late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation 1.18 [0.57;2.43] C 28/59   26/60 54 59
ref
Total 1 studies 1.18 [0.57;2.43] 54 59
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cluver, 2018Cluver, 2018 1.18[0.57; 2.43]54590%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.18[0.57; 2.43]5459 -NACluver, 2018 1 Type of controls unexposed, sickunexposed, sick 1.18[0.57; 2.43]5459 -NACluver, 2018 1 Tags Adjustment   - Randomisation  - Randomisation 1.18[0.57; 2.43]5459 -NACluver, 2018 1 All studiesAll studies 1.18[0.57; 2.43]5459 -NACluver, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.18[0.57; 2.43]5459 -NACluver, 2018 10.510.01.0