Lansoprazole

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8550
R28448		 Fejzo, 2015 Neurodevelopmental delay (Diagnosis of ADD/ADHD; Learning difficulties delays; social development delay or social anxiety; speech or language impairment/delay) during pregnancy (anytime or not specified) case control unexposed, sick Adjustment: No 2.00 [0.87;4.60] C 15/25   123/287 138 25
ref
Total 1 studies 2.00 [0.87;4.60] 138 25
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fejzo, 2015Fejzo, 2015 2.00[0.87; 4.60]138250%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.00[0.87; 4.60]13825 -NAFejzo, 2015 1 Type of controls unexposed, sickunexposed, sick 2.00[0.87; 4.60]13825 -NAFejzo, 2015 1 Tags Adjustment   - No  - No 2.00[0.87; 4.60]13825 -NAFejzo, 2015 1 All studiesAll studies 2.00[0.87; 4.60]13825 -NAFejzo, 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.00[0.87; 4.60]13825 -NAFejzo, 2015 10.510.01.0