Lansoprazole

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14456
R57398		 Choi a, 2023 Hypospadias 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.00 [0.41;2.42] 5/3,284   1,799/1,371,387 1,804 3,284
ref
S4803
R12326		 Lind, 2013 Isolated Second- or Third-Degree Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 2.80 [0.80;9.80] 6/12   1,531/5,839 1,537 12
ref
S4433
R10489		 Källèn, 1998 Hypospadias 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 5.05 [0.20;130.52] C 0/13   1/191 1 13
ref
Total 3 studies 1.57 [0.70;3.51] 3,342 3,309
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi a, 2023Choi a, 2023 1.00[0.41; 2.42]1,8043,28460%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: NAROB reporting: NA Lind, 2013Lind, 2013 2.80[0.80; 9.80]1,5371235%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Källèn, 1998Källèn, 1998 5.05[0.20; 130.52]1136%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 13% 1.57[0.70; 3.51]3,3423,3090.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.48; 2.63]1,8053,2970%NAChoi a, 2023 Källèn, 1998 2 case control studiescase control studies 2.80[0.80; 9.80]1,53712 -NALind, 2013 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.80[0.80; 9.80]1,53712 -NALind, 2013 1 unexposed, sickunexposed, sick 1.00[0.41; 2.43]1,8043,284 -NAChoi a, 2023 1 exposed to other treatment, sickexposed to other treatment, sick 5.05[0.20; 130.52]113 -NAKällèn, 1998 1 Tags Adjustment   - No  - No 5.05[0.20; 130.52]113 -NAKällèn, 1998 1   - Yes  - Yes 1.52[0.56; 4.08]3,3413,29642%NAChoi a, 2023 Lind, 2013 2 All studiesAll studies 1.57[0.70; 3.51]3,3423,30913%NAChoi a, 2023 Lind, 2013 Källèn, 1998 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.80[0.80; 9.80]1,53712 -NALind, 2013 1 unexposed, sick controlsunexposed, sick controls 1.00[0.41; 2.43]1,8043,284 -NAChoi a, 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.05[0.20; 130.52]113 -NAKällèn, 1998 10.510.01.0