Lansoprazole

Down syndrom / Trisomy 21

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4433
R11014		 Källèn, 1998 Down's syndrome 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 15.24 [0.29;800.69] C 0/13   0/191 0 13
ref
Total 1 studies 15.24 [0.29;800.69] 0 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källèn, 1998Källèn, 1998 15.24[0.29; 800.69]0130%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 15.24[0.29; 800.69]-13 -NAKällèn, 1998 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 15.24[0.29; 800.69]-13 -NAKällèn, 1998 1 Tags Adjustment   - No  - No 15.24[0.29; 800.69]-13 -NAKällèn, 1998 1 All studiesAll studies 15.24[0.29; 800.69]-13 -NAKällèn, 1998 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale15.24[0.29; 800.69]-13 -NAKällèn, 1998 10.510.01.0