Lansoprazole updated on 08-08-2023

Genetic syndromes and microdeletions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18812
R80047		 Broe (Controls unexposed, general pop), 2025 Syndromes 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.98 [1.12;3.51]
excluded (control group) 		12/3,534   797/478,736 809 3,534
ref
S18816
R80049		 Broe (Controls unexposed, sick), 2025 Syndromes 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.43 [0.69;2.97] 12/3,534   19/7,148 31 3,534
ref
Total 1 studies 1.43 [0.69;2.97] 31 3,534
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Broe (Controls unexposed, sick), 2025Broe, 2025 1 1.43[0.69; 2.97]313,5340%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.69; 2.97]313,534 -NABroe (Controls unexposed, sick), 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.43[0.69; 2.97]313,534 -NABroe (Controls unexposed, sick), 2025 1 Tags Adjustment   - Yes  - Yes 1.43[0.69; 2.97]313,534 -NABroe (Controls unexposed, sick), 2025 1 All studiesAll studies 1.43[0.69; 2.97]313,534 -NABroe (Controls unexposed, sick), 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18812

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.98[1.12; 3.51]8093,534 -NABroe (Controls unexposed, general pop), 2025 1 unexposed, sick controlsunexposed, sick controls 1.43[0.69; 2.97]313,534 -NABroe (Controls unexposed, sick), 2025 10.510.01.0