| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18812 R80041 |
Broe (Controls unexposed, general pop), 2025 | Major congenital malformations (exclusion of chromosomal abnormalities (ICD-10 codes Q90– Q99)) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.33 [1.14;1.57] excluded (control group) |
172/3,534 17,235/478,736 | 17,407 | 3,534 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18816 R80045 |
Broe (Controls unexposed, sick), 2025 | Major congenital malformations (exclusion of chromosomal abnormalities (ICD-10 codes Q90– Q99)) | 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.29 [1.05;1.59] | 172/3,534 280/7,148 | 452 | 3,534 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18828 R80158 |
Hongoh, 2025 | Major malformations | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes | 0.51 [0.07;3.79] | 1/96 31/1,669 | 32 | 96 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S14456 R57394 |
Choi a, 2023 | Major congenital malformations | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.01 [0.89;1.15] | 233/6,404 85,900/2,655,676 | 86,133 | 6,404 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S4448 R10563 |
Matok, 2012 | Major malformations (according to CDC definitions) | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 0.83 [0.48;1.46] | 13/233 6,753/110,550 | 6,766 | 233 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S4410 R10440 |
Pasternak, 2010 | Major birth defects (Exposure during First Trimester) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes | 1.13 [0.77;1.67] | 28/794 21,867/837,317 | 21,895 | 794 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S4429 R10472 |
Diav-Citrin, 2005 | Major anomalies | 1st trimester | prospective cohort | unexposed (general population or NOS) | Adjustment: No | 1.21 [0.28;5.23] C | 2/44 30/792 | 32 | 44 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 6 studies | 1.08 [0.96;1.21] | 115,310 | 11,105 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, sick;
Asymetry test p-value = 0.8404 (by Egger's regression)
slope=0.0855 (0.0930); intercept=-0.1557 (0.7247); t=0.2148; p=0.8404
excluded 18812