Lansoprazole updated on 08-08-2023

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18828
R80160		 Hongoh, 2025 Spontaneous miscarriages (fetal death before 22 weeks of gestation) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.30 [0.55;3.05] C 6/106   79/1,787 85 106
ref
S4429
R10733		 Diav-Citrin, 2005 Miscarriage during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.50 [0.62;3.62] C 6/62   58/868 64 62
ref
Total 2 studies 1.39 [0.75;2.57] 149 168
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hongoh, 2025Hongoh, 2025 1.30[0.55; 3.05]8510652%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: critical Diav-Citrin, 2005Diav-Citrin, 2005 1.50[0.62; 3.62]646248%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.39[0.75; 2.57]1491680.55.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.39[0.75; 2.57]1491680%NAHongoh, 2025 Diav-Citrin, 2005 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.39[0.75; 2.57]1491680%NAHongoh, 2025 Diav-Citrin, 2005 2 Tags Adjustment   - No  - No 1.39[0.75; 2.57]1491680%NAHongoh, 2025 Diav-Citrin, 2005 2 All studiesAll studies 1.39[0.75; 2.57]1491680%NAHongoh, 2025 Diav-Citrin, 2005 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.39[0.75; 2.57]1491680%NAHongoh, 2025 Diav-Citrin, 2005 20.510.01.0