Lansoprazole updated on 08-08-2023

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18828
R80161		 Hongoh, 2025 Induced abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 3.44 [0.98;12.08] C 3/106   15/1,788 18 106
ref
S4429
R10734		 Diav-Citrin, 2005 Elective termination of pregnancy during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 3.96 [1.65;9.51] C 7/62   27/868 34 62
ref
Total 2 studies 3.79 [1.85;7.76] 52 168
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hongoh, 2025Hongoh, 2025 3.44[0.98; 12.08]1810633%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: critical Diav-Citrin, 2005Diav-Citrin, 2005 3.96[1.65; 9.51]346267%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 3.79[1.85; 7.76]521680.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.79[1.85; 7.76]521680%NAHongoh, 2025 Diav-Citrin, 2005 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.79[1.85; 7.76]521680%NAHongoh, 2025 Diav-Citrin, 2005 2 Tags Adjustment   - No  - No 3.79[1.85; 7.76]521680%NAHongoh, 2025 Diav-Citrin, 2005 2 All studiesAll studies 3.79[1.85; 7.76]521680%NAHongoh, 2025 Diav-Citrin, 2005 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.79[1.85; 7.76]521680%NAHongoh, 2025 Diav-Citrin, 2005 20.510.01.0