Lansoprazole updated on 08-08-2023

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18828
R80163		 Hongoh, 2025 Low birth weight infants (<2500 g) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.28 [0.60;2.70] C 8/96   111/1,668 119 96
ref
S15111
R62073		 Choi b, 2023 Low birth weight (perinatal weight <2.5 kg) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.91 [0.83;1.00] 482/8,678   104,056/2,121,323 104,538 8,678
ref
Total 2 studies 0.91 [0.83;1.00] 104,657 8,774
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hongoh, 2025Hongoh, 2025 1.28[0.60; 2.70]119962%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: critical Choi b, 2023Choi b, 2023 0.91[0.83; 1.00]104,5388,67898%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.91[0.83; 1.00]104,6578,7740.25.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.83; 1.00]104,6578,7740%NAHongoh, 2025 Choi b, 2023 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.28[0.60; 2.70]11996 -NAHongoh, 2025 1 unexposed, sickunexposed, sick 0.91[0.83; 1.00]104,5388,678 -NAChoi b, 2023 1 Tags Adjustment   - No  - No 1.28[0.60; 2.70]11996 -NAHongoh, 2025 1   - Yes  - Yes 0.91[0.83; 1.00]104,5388,678 -NAChoi b, 2023 1 All studiesAll studies 0.91[0.83; 1.00]104,6578,7740%NAHongoh, 2025 Choi b, 2023 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.60; 2.70]11996 -NAHongoh, 2025 1 unexposed, sick controlsunexposed, sick controls 0.91[0.83; 1.00]104,5388,678 -NAChoi b, 2023 10.510.01.0