Rabeprazole

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14454
R57400		 Choi a, 2023 Major congenital malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.03 [0.95;1.13] 505/13,414   85,900/2,655,676 86,405 13,414
ref
S4411
R28451		 Pasternak, 2010 Major birth defects (Exposure during First Trimester) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 2.14 [0.60;7.68] 3/42   21,867/837,317 21,870 42
ref
Total 2 studies 1.11 [0.72;1.73] 108,275 13,456
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi a, 2023Choi a, 2023 1.03[0.95; 1.13]86,40513,41489%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: NAROB reporting: NA Pasternak, 2010Pasternak, 2010 2.14[0.60; 7.68]21,8704211%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 21% 1.11[0.72; 1.73]108,27513,4560.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.72; 1.73]108,27513,45621%NAChoi a, 2023 Pasternak, 2010 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.14[0.60; 7.66]21,87042 -NAPasternak, 2010 1 unexposed, sickunexposed, sick 1.03[0.94; 1.12]86,40513,414 -NAChoi a, 2023 1 Tags Adjustment   - Yes  - Yes 1.11[0.72; 1.73]108,27513,45621%NAChoi a, 2023 Pasternak, 2010 2 All studiesAll studies 1.11[0.72; 1.73]108,27513,45621%NAChoi a, 2023 Pasternak, 2010 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.14[0.60; 7.66]21,87042 -NAPasternak, 2010 1 unexposed, sick controlsunexposed, sick controls 1.03[0.94; 1.12]86,40513,414 -NAChoi a, 2023 10.510.01.0