Tenofovir (all routes except local)

Jaundice / Icterus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5259
R13617		 Pan, 2016 Jaundice late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.87 [0.17;21.00] C 2/95   1/88 3 95
ref
Total 1 studies 1.87 [0.17;21.00] 3 95
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pan, 2016Pan, 2016 1.87[0.17; 21.00]3950%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.87[0.17; 21.00]395 -NAPan, 2016 1 Type of controls unexposed, sickunexposed, sick 1.87[0.17; 21.00]395 -NAPan, 2016 1 Tags Adjustment   - Randomisation  - Randomisation 1.87[0.17; 21.00]395 -NAPan, 2016 1 Control group   - Unexposed, sick  - Unexposed, sick 1.87[0.17; 21.00]395 -NAPan, 2016 1 Exposed group   - TDF (only)  - TDF (only) 1.87[0.17; 21.00]395 -NAPan, 2016 1 Indication   - CHB  - CHB 1.87[0.17; 21.00]395 -NAPan, 2016 1 All studiesAll studies 1.87[0.17; 21.00]395 -NAPan, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.87[0.17; 21.00]395 -NAPan, 2016 10.510.01.0