Tenofovir (all routes except local)

Hypothyroidism (fetal/neonatal)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
Celen, 2013 Neonatal Hypothyroidism 2nd and/or 3rd trimester retrospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.10 [0.02;57.89] C 0/21   0/23 0 21
Total 1 studies 1.10 [0.02;57.89] 0 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Celen, 2013Celen, 2013 1.10[0.02; 57.89]0210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.02; 57.89]-21 -NACelen, 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.10[0.02; 57.89]-21 -NACelen, 2013 1 Tags Adjustment   - No  - No 1.10[0.02; 57.89]-21 -NACelen, 2013 1 Control group   - Unexposed, sick  - Unexposed, sick 1.10[0.02; 57.89]-21 -NACelen, 2013 1 Exposed group   - TDF (only)  - TDF (only) 1.10[0.02; 57.89]-21 -NACelen, 2013 1 Indication   - CHB  - CHB 1.10[0.02; 57.89]-21 -NACelen, 2013 1 All studiesAll studies 1.10[0.02; 57.89]-21 -NACelen, 2013

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies


Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.10[0.02; 57.89]-21 -NACelen, 2013 10.510.01.0