Tenofovir (all routes except local)

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5175
R13493		 Liu (Controls exposed to LDT), 2019 1 min Apgar Score < 10 3rd trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Control group: telbivudine Exposed group: TDF (only) Indication: CHB 0.98 [0.38;2.52] C
excluded (control group) 		8/325   10/400 18 325
ref
S5174
R13486		 Liu (Controls unexposed, sick), 2019 1 min Apgar Score < 10 3rd trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 3.41 [0.42;27.51] C 8/325   1/136 9 325
ref
S5304
R13747		 Jourdain a, 2018 Apgar score < 7 (at 1 min) 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 0.65 [0.11;3.92] C 2/163   3/159 5 163
ref
S5321
R13799		 Lin, 2018 Low Apgar scores (<7) at 1 min 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.85 [0.16;21.08] C 2/57   1/52 3 57
ref
S5244
R13563		 Greenup (Controls exposed to lamivudine), 2014 Abnormal APGAR < 8 (1min) 2nd and/or 3rd trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Control group: Lamivudine Exposed group: TDF (only) Indication: CHB 0.36 [0.10;1.26] C
excluded (control group) 		4/58   9/53 13 58
ref
S5243
R13553		 Greenup (Controls unexposed, sick), 2014 Abnormal APGAR < 8 (1min) 2nd and/or 3rd trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.41 [0.15;13.39] C 4/58   1/20 5 58
ref
Total 4 studies 1.42 [0.50;4.07] 22 603
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liu (Controls unexposed, sick), 2019Liu, 2019 1 3.41[0.42; 27.51]932525%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Jourdain a, 2018Jourdain a, 2018 0.65[0.11; 3.92]516334%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Lin, 2018Lin, 2018 1.85[0.16; 21.08]35719%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Greenup (Controls unexposed, sick), 2014Greenup, 2014 2 1.41[0.15; 13.39]55822%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.42[0.50; 4.07]226030.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[0.49; 10.47]143830%NALiu (Controls unexposed, sick), 2019 Greenup (Controls unexposed, sick), 2014 2 case control studiescase control studies 0 RCTRCT 0.94[0.22; 4.00]82200%NAJourdain a, 2018 Lin, 2018 2 Type of controls unexposed, sickunexposed, sick 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 4 Tags Adjustment   - No  - No 2.26[0.49; 10.47]143830%NALiu (Controls unexposed, sick), 2019 Greenup (Controls unexposed, sick), 2014 2   - Randomisation  - Randomisation 0.94[0.22; 4.00]82200%NAJourdain a, 2018 Lin, 2018 2 Control group   - Unexposed, sick  - Unexposed, sick 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 4 Exposed group   - TDF (only)  - TDF (only) 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 4 Indication   - CHB  - CHB 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 4 All studiesAll studies 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 40.210.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.93.31.4880.000Liu (Controls unexposed, sick), 2019Jourdain a, 2018Lin, 2018Greenup (Controls unexposed, sick), 2014

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 5244, 5175

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.42[0.50; 4.07]226030%NALiu (Controls unexposed, sick), 2019 Jourdain a, 2018 Lin, 2018 Greenup (Controls unexposed, sick), 2014 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.65[0.25; 1.71]3138337%NALiu (Controls exposed to LDT), 2019 Greenup (Controls exposed to lamivudine), 2014 20.510.01.0