Tenofovir (all routes except local)

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5244
R13564		 Greenup (Controls exposed to lamivudine), 2014 Abnormal APGAR < 8 (5min) 2nd and/or 3rd trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Control group: Lamivudine Exposed group: TDF (only) Indication: CHB 0.91 [0.02;46.84] C
excluded (control group) 		0/58   0/53 0 58
ref
S5243
R13554		 Greenup (Controls unexposed, sick), 2014 Abnormal APGAR < 8 (5min) 2nd and/or 3rd trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 0.11 [0.00;2.75] C 0/58   1/20 1 58
ref
Total 1 studies 0.11 [0.00;2.75] 1 58
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Greenup (Controls unexposed, sick), 2014Greenup, 2014 1 0.11[0.00; 2.75]1580%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 Control group   - Unexposed, sick  - Unexposed, sick 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 Exposed group   - TDF (only)  - TDF (only) 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 Indication   - CHB  - CHB 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 All studiesAll studies 0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5244

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.11[0.00; 2.75]158 -NAGreenup (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.02; 46.84]-58 -NAGreenup (Controls exposed to lamivudine), 2014 10.510.01.0