Tenofovir (all routes except local)

Oligohydramnios

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5244
R13557		 Greenup (Controls exposed to lamivudine), 2014 Oligohydramnios 2nd and/or 3rd trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Control group: Lamivudine Exposed group: TDF (only) Indication: CHB 0.91 [0.06;14.96] C
excluded (control group) 		1/58   1/53 2 58
ref
S5243
R13547		 Greenup (Controls unexposed, sick), 2014 Oligohydramnios 2nd and/or 3rd trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.04 [0.04;26.49] C 1/58   0/20 1 58
ref
Total 1 studies 1.04 [0.04;26.49] 1 58
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Greenup (Controls unexposed, sick), 2014Greenup, 2014 1 1.04[0.04; 26.49]1580%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 Control group   - Unexposed, sick  - Unexposed, sick 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 Exposed group   - TDF (only)  - TDF (only) 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 Indication   - CHB  - CHB 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 All studiesAll studies 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5244

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.04[0.04; 26.49]158 -NAGreenup (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.06; 14.96]258 -NAGreenup (Controls exposed to lamivudine), 2014 10.510.01.0