Tenofovir (all routes except local)

Placenta previa

id	Study   Auto Lin, 2018Pan, 2016	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S5321 R13776	Lin, 2018	Placenta previa	3rd trimester excluded	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB	0.88 [0.02;45.17] C excluded (exposition period)	0/59   0/52	0	59		ref
S5259 R13599	Pan, 2016	Placenta previa	late pregnancy excluded	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB	5.26 [0.25;111.10] C excluded (exposition period)	2/97   0/100	2	97		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis