Tenofovir (all routes except local)

Large for gestational age (length)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
Vigano, 2011 Length at birth (>90th percentile) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No Control group: non-TDF (mix or unspecified regimens) Exposed group: TDF (mix or unspecified regimens) Indication: HIV 2.19 [0.19;25.40] C 2/33   1/35 3 33
Total 1 studies 2.19 [0.19;25.40] 3 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vigano, 2011Vigano, 2011 2.19[0.19; 25.40]3330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.19[0.19; 25.40]333 -NAVigano, 2011 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 2.19[0.19; 25.40]333 -NAVigano, 2011 1 Tags Adjustment   - No  - No 2.19[0.19; 25.40]333 -NAVigano, 2011 1 Control group   - non-TDF (mix or unspecified regimens)  - non-TDF (mix or unspecified regimens) 2.19[0.19; 25.40]333 -NAVigano, 2011 1 Exposed group   - TDF (mix or unspecified regimens)  - TDF (mix or unspecified regimens) 2.19[0.19; 25.40]333 -NAVigano, 2011 1 Indication   - HIV  - HIV 2.19[0.19; 25.40]333 -NAVigano, 2011 1 All studiesAll studies 2.19[0.19; 25.40]333 -NAVigano, 2011

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies


Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.19[0.19; 25.40]333 -NAVigano, 2011 10.510.01.0