Tenofovir (all routes except local)

Very low Apgar score (< 5) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5304
R13744		 Jourdain a, 2018 Apgar score 0-3 (at 1 min) 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 1.96 [0.18;21.86] C 2/163   1/159 3 163
ref
S5321
R13803		 Lin, 2018 Apgar score 0-3 severe suffocation (at 1 min) 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 0.91 [0.02;46.78] C 0/57   0/52 0 57
ref
Total 2 studies 1.59 [0.20;12.44] 3 220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jourdain a, 2018Jourdain a, 2018 1.96[0.18; 21.86]316373%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Lin, 2018Lin, 2018 0.91[0.02; 46.78]05727%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.59[0.20; 12.44]32200.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 Type of controls unexposed, sickunexposed, sick 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 Tags Adjustment   - Randomisation  - Randomisation 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 Control group   - Unexposed, sick  - Unexposed, sick 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 Exposed group   - TDF (only)  - TDF (only) 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 Indication   - CHB  - CHB 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 2 All studiesAll studies 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.59[0.20; 12.44]32200%NAJourdain a, 2018 Lin, 2018 20.510.01.0