Tenofovir (all routes except local)

Mitochondrial abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
Crain, 2011 Neonatal blood lactate concentration above a threshold of 3mmol/L during pregnancy (anytime or not specified) cohort exposed to other treatment, sick Adjustment: Yes Control group: non-TDF (mix or unspecified regimens) Exposed group: TDF (mix or unspecified regimens) Indication: HIV 1.85 [0.96;3.54] 15/299   36/1,273 51 299
Total 1 studies 1.85 [0.96;3.55] 51 299
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Crain, 2011Crain, 2011 1.85[0.96; 3.54]512990%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.85[0.96; 3.55]51299 -NACrain, 2011 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.85[0.96; 3.55]51299 -NACrain, 2011 1 Tags Adjustment   - Yes  - Yes 1.85[0.96; 3.55]51299 -NACrain, 2011 1 Control group   - non-TDF (mix or unspecified regimens)  - non-TDF (mix or unspecified regimens) 1.85[0.96; 3.55]51299 -NACrain, 2011 1 Exposed group   - TDF (mix or unspecified regimens)  - TDF (mix or unspecified regimens) 1.85[0.96; 3.55]51299 -NACrain, 2011 1 Indication   - HIV  - HIV 1.85[0.96; 3.55]51299 -NACrain, 2011 1 All studiesAll studies 1.85[0.96; 3.55]51299 -NACrain, 2011

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies


Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.85[0.96; 3.55]51299 -NACrain, 2011 10.510.01.0