Tenofovir (all routes except local)

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5131
R13355		 Fowler, 2016 Genitourinary malformations (genital malfo only) 2nd and/or 3rd trimester excluded randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation Control group: zidovudine/lamivudine/lopinavir–ritonavir Exposed group: TDF/emtricitabine/lopinavir–ritonavir Indication: HIV 0.20 [0.01;4.26] C
excluded (exposition period) 		0/320   2/328 2 320
ref
S5132
R13371		 Floridia, 2013 Genital anomalies 1st trimester prospective cohort unexposed, sick Adjustment: No Control group: Unexposed, sick Exposed group: TDF (mix or unspecified regimens) Indication: HIV 1.63 [0.15;18.03] C 1/173   2/561 3 173
ref
Total 1 studies 1.63 [0.15;18.03] 3 173
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Floridia, 2013Floridia, 2013 1.63[0.15; 18.03]31730%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 Tags Adjustment   - No  - No 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 Control group   - Unexposed, sick  - Unexposed, sick 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 Exposed group   - TDF (mix or unspecified regimens)  - TDF (mix or unspecified regimens) 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 Indication   - HIV  - HIV 1.63[0.15; 18.03]3173 -NAFloridia, 2013 1 All studiesAll studies 1.63[0.15; 18.03]3173 -NAFloridia, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.63[0.15; 18.03]3173 -NAFloridia, 2013 10.510.01.0