Tenofovir (all routes except local)

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5259
R13607
Pan, 2016 Macrosomia (NOS) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: CHB 7.45 [0.38;146.17] C 3/97   0/100 3 97
ref
S5121
R13270
Vigano, 2011 High birthweight (>90th percentile) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No Control group: non-TDF (mix or unspecified regimens) Exposed group: TDF (mix or unspecified regimens) Indication: HIV 1.06 [0.06;17.71] C 1/33   1/35 2 33
ref
Total 2 studies 2.66 [0.34;20.58] 5 130
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pan, 2016Pan, 2016 7.45[0.38; 146.17]39747%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vigano, 2011Vigano, 2011 1.06[0.06; 17.71]23353%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.66[0.34; 20.58]51300.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.66[0.34; 20.58]51300%NAPan, 2016 Vigano, 2011 2 case control studiescase control studies 0 RCTRCT 7.45[0.38; 146.17]397 -NAPan, 2016 1 Type of controls unexposed, sickunexposed, sick 7.45[0.38; 146.17]397 -NAPan, 2016 1 exposed to other treatment, sickexposed to other treatment, sick 1.06[0.06; 17.71]233 -NAVigano, 2011 1 Tags Adjustment   - No  - No 1.06[0.06; 17.71]233 -NAVigano, 2011 1   - Randomisation  - Randomisation 7.45[0.38; 146.17]397 -NAPan, 2016 1 Control group   - non-TDF (mix or unspecified regimens)  - non-TDF (mix or unspecified regimens) 1.06[0.06; 17.71]233 -NAVigano, 2011 1   - Unexposed, sick  - Unexposed, sick 7.45[0.38; 146.17]397 -NAPan, 2016 1 Exposed group   - TDF (mix or unspecified regimens)  - TDF (mix or unspecified regimens) 1.06[0.06; 17.71]233 -NAVigano, 2011 1   - TDF (only)  - TDF (only) 7.45[0.38; 146.17]397 -NAPan, 2016 1 Indication   - CHB  - CHB 7.45[0.38; 146.17]397 -NAPan, 2016 1   - HIV  - HIV 1.06[0.06; 17.71]233 -NAVigano, 2011 1 All studiesAll studies 2.66[0.34; 20.58]51300%NAPan, 2016 Vigano, 2011 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.45[0.38; 146.17]397 -NAPan, 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.06; 17.71]233 -NAVigano, 2011 10.510.01.0