Tramadol (versus unexposed) updated on 07-09-2025

Tumors in infants

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13279
R51134		 Bowie, 2022 Neoplasms and tumours at least 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 4.71 [1.98;11.17] 5/781   886/587,676 891 781
ref
Total 1 studies 4.71 [1.98;11.19] 891 781
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bowie, 2022Bowie, 2022 4.71[1.98; 11.17]8917810%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.71[1.98; 11.19]891781 -NABowie, 2022 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.71[1.98; 11.19]891781 -NABowie, 2022 1 Tags Adjustment   - Yes  - Yes 4.71[1.98; 11.19]891781 -NABowie, 2022 1 All studiesAll studies 4.71[1.98; 11.19]891781 -NABowie, 2022 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.71[1.98; 11.19]891781 -NABowie, 2022 10.510.01.0