Tacrolimus (all routes)

Maternal consequences (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5779
R14342		 Sugawara, 2019 Maternal adverse events (any events including disease flares, emergency cesarean sections, PROM, preterm deliveries, GDM, HDP, HELLP syndrome, or eclampsia) during pregnancy (anytime or not specified) nested case control exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 1.18 [0.36;3.87] C 10/16   24/41 34 16
ref
Total 1 studies 1.18 [0.36;3.87] 34 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sugawara, 2019Sugawara, 2019 1.18[0.36; 3.87]34160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.18[0.36; 3.87]3416 -NASugawara, 2019 1 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.18[0.36; 3.87]3416 -NASugawara, 2019 1 Tags Adjustment   - No  - No 1.18[0.36; 3.87]3416 -NASugawara, 2019 1 Co-exposure Mycophenolate   - no  - no 1.18[0.36; 3.87]3416 -NASugawara, 2019 1 All studiesAll studies 1.18[0.36; 3.87]3416 -NASugawara, 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.18[0.36; 3.87]3416 -NASugawara, 2019 10.510.01.0