Tacrolimus (all routes)

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5780
R14453		 Wielgos, 2012 Gestational diabetes throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 1.31 [0.05;35.47] C 1/21   0/9 1 21
ref
Total 1 studies 1.31 [0.05;35.47] 1 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wielgos, 2012Wielgos, 2012 1.31[0.05; 35.47]1210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.31[0.05; 35.47]121 -NAWielgos, 2012 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.31[0.05; 35.47]121 -NAWielgos, 2012 1 Tags Adjustment   - No  - No 1.31[0.05; 35.47]121 -NAWielgos, 2012 1 Co-exposure Mycophenolate   - no  - no 1.31[0.05; 35.47]121 -NAWielgos, 2012 1 All studiesAll studies 1.31[0.05; 35.47]121 -NAWielgos, 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.31[0.05; 35.47]121 -NAWielgos, 2012 10.510.01.0