Tacrolimus (all routes)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5638
R14047		 Alvaro, 2013 Pregnancy-induced hypertension or preeclampsia throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 3.86 [0.17;87.66] C 4/15   0/5 4 15
ref
S12404
R46258		 Perales-Puchalt, 2012 Preeclampsia (presence of hypertension and proteinuria, with or without pathological edema) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 1.25 [0.07;23.26] C 1/9   1/11 2 9
ref
S5780
R14452		 Wielgos, 2012 Preeclampsia throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 1.88 [0.18;19.68] C 4/21   1/9 5 21
ref
S5783
R46252		 Thompson, 2003 Pre-eclampsia throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 2.83 [0.32;24.81] C 2/4   6/23 8 4
ref
Total 4 studies 2.26 [0.63;8.11] 19 49
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Alvaro, 2013Alvaro, 2013 3.86[0.17; 87.66]41517%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Perales-Puchalt, 2012Perales-Puchalt, 2012 1.25[0.07; 23.26]2919%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Wielgos, 2012Wielgos, 2012 1.88[0.18; 19.68]52130%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Thompson, 2003Thompson, 2003 2.83[0.32; 24.81]8435%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 2.26[0.63; 8.11]19490.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 4 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 4 Tags Adjustment   - No  - No 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 4 Co-exposure Mycophenolate   - no  - no 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 4 All studiesAll studies 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.74.61.9120.000Alvaro, 2013Perales-Puchalt, 2012Wielgos, 2012Thompson, 2003

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.26[0.63; 8.11]19490%NAAlvaro, 2013 Perales-Puchalt, 2012 Wielgos, 2012 Thompson, 2003 40.510.01.0