Tacrolimus (all routes)

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5781
R14513		 Ichinose, 2018 Non-reassuring fetal status (suspected fetal hypoxia) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: Yes Co-exposure Mycophenolate: no 0.48 [0.04;4.66] -/15   -/39 - 15
ref
Total 1 studies 0.48 [0.04;5.18] 0 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ichinose, 2018Ichinose, 2018 0.48[0.04; 4.66]-150%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.48[0.04; 5.18]-15 -NAIchinose, 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.48[0.04; 5.18]-15 -NAIchinose, 2018 1 Tags Adjustment   - Yes  - Yes 0.48[0.04; 5.18]-15 -NAIchinose, 2018 1 Co-exposure Mycophenolate   - no  - no 0.48[0.04; 5.18]-15 -NAIchinose, 2018 1 All studiesAll studies 0.48[0.04; 5.18]-15 -NAIchinose, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.48[0.04; 5.18]-15 -NAIchinose, 2018 10.510.01.0