Tacrolimus (all routes)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12404
R46254		 Perales-Puchalt, 2012 Malformation throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 1.00 [0.02;56.47] C 0/9   0/9 0 9
ref
S5780
R14503		 Wielgos, 2012 Major congenital malformations throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 0.37 [0.04;3.14] C 2/21   2/9 4 21
ref
Total 2 studies 0.46 [0.07;3.05] 4 30
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Perales-Puchalt, 2012Perales-Puchalt, 2012 1.00[0.02; 56.47]0922%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Wielgos, 2012Wielgos, 2012 0.37[0.04; 3.14]42178%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.46[0.07; 3.05]4300.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 2 Tags Adjustment   - No  - No 0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 2 Co-exposure Mycophenolate   - no  - no 0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 2 All studiesAll studies 0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.46[0.07; 3.05]4300%NAPerales-Puchalt, 2012 Wielgos, 2012 20.510.01.0