Tacrolimus (all routes)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5780
R14502		 Wielgos, 2012 Major congenital malformations throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 0.37 [0.04;3.14] C 2/21   2/9 4 21
ref
Total 1 studies 0.37 [0.04;3.14] 4 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wielgos, 2012Wielgos, 2012 0.37[0.04; 3.14]4210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.04; 3.14]421 -NAWielgos, 2012 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.37[0.04; 3.14]421 -NAWielgos, 2012 1 Tags Adjustment   - No  - No 0.37[0.04; 3.14]421 -NAWielgos, 2012 1 Co-exposure Mycophenolate   - no  - no 0.37[0.04; 3.14]421 -NAWielgos, 2012 1 All studiesAll studies 0.37[0.04; 3.14]421 -NAWielgos, 2012 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.37[0.04; 3.14]421 -NAWielgos, 2012 10.510.01.0