Tacrolimus (all routes)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5633
R14217		 Al-Otaibi, 2019 Abortion throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no Matched 7.95 [0.37;171.28] C 2/33   0/49 2 33
ref
Total 1 studies 7.95 [0.37;171.28] 2 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Al-Otaibi, 2019Al-Otaibi, 2019 7.95[0.37; 171.28]2330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 1 Tags Adjustment   - No  - No 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 1 Co-exposure Mycophenolate   - no  - no 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 1 MatchedMatched 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 1 All studiesAll studies 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 7.95[0.37; 171.28]233 -NAAl-Otaibi, 2019 10.510.01.0