Tacrolimus (all routes)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5633
R14216		 Al-Otaibi, 2019 Intrauterine fetal death throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no Matched 4.62 [0.18;116.99] C 1/33   0/49 1 33
ref
S12404
R46253		 Perales-Puchalt, 2012 Stillbirths throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 0.20 [0.01;4.82] C 0/9   2/11 2 9
ref
Total 2 studies 0.95 [0.04;20.57] 3 42
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Al-Otaibi, 2019Al-Otaibi, 2019 4.62[0.18; 116.99]13350%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Perales-Puchalt, 2012Perales-Puchalt, 2012 0.20[0.01; 4.82]2950%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 46% 0.95[0.04; 20.57]3420.010.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 2 Tags Adjustment   - No  - No 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 2 Co-exposure Mycophenolate   - no  - no 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 2 MatchedMatched 4.62[0.18; 116.99]133 -NAAl-Otaibi, 2019 1 All studiesAll studies 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.95[0.04; 20.57]34246%NAAl-Otaibi, 2019 Perales-Puchalt, 2012 20.510.01.0