Tacrolimus (all routes)

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5633
R14215		 Al-Otaibi, 2019 Premature throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no Matched 0.51 [0.10;2.72] C 2/30   6/49 8 30
ref
S5781
R14288		 Ichinose, 2018 Preterm birth (23 and 36 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: Yes Co-exposure Mycophenolate: no 0.68 [0.07;5.25] -/15   -/39 - 15
ref
S12402
R46230		 Kim, 2015 Preterm delivery (< 37 wk) throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 2.49 [0.99;6.25] C 15/28   19/60 34 28
ref
S12404
R46261		 Perales-Puchalt, 2012 Prematurity or preterm birth (childbirth before 37 weeks of pregnancy) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 0.40 [0.06;2.70] C 3/9   5/9 8 9
ref
Total 4 studies 0.99 [0.36;2.69] 50 82
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Al-Otaibi, 2019Al-Otaibi, 2019 0.51[0.10; 2.72]83023%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ichinose, 2018Ichinose, 2018 0.68[0.07; 5.25]-1516%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Kim, 2015Kim, 2015 2.49[0.99; 6.25]342842%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: unclearROB mesure: moderateROB reporting: moderate Perales-Puchalt, 2012Perales-Puchalt, 2012 0.40[0.06; 2.70]8919%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 39% 0.99[0.36; 2.69]50820.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.99[0.36; 2.69]508239%NAAl-Otaibi, 2019 Ichinose, 2018 Kim, 2015 Perales-Puchalt, 2012 4 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.68[0.08; 5.89]-15 -NAIchinose, 2018 1 exposed to other treatment, sickexposed to other treatment, sick 0.98[0.28; 3.51]506756%NAAl-Otaibi, 2019 Kim, 2015 Perales-Puchalt, 2012 3 Tags Adjustment   - No  - No 0.98[0.28; 3.51]506756%NAAl-Otaibi, 2019 Kim, 2015 Perales-Puchalt, 2012 3   - Yes  - Yes 0.68[0.08; 5.89]-15 -NAIchinose, 2018 1 Co-exposure Mycophenolate   - no  - no 0.99[0.36; 2.69]508239%NAAl-Otaibi, 2019 Ichinose, 2018 Kim, 2015 Perales-Puchalt, 2012 4 MatchedMatched 0.51[0.10; 2.72]830 -NAAl-Otaibi, 2019 1 All studiesAll studies 0.99[0.36; 2.69]508239%NAAl-Otaibi, 2019 Ichinose, 2018 Kim, 2015 Perales-Puchalt, 2012 40.15.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.62.61.3220.000Al-Otaibi, 2019Ichinose, 2018Kim, 2015Perales-Puchalt, 2012

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.68[0.08; 5.89]-15 -NAIchinose, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.98[0.28; 3.51]506756%NAAl-Otaibi, 2019 Kim, 2015 Perales-Puchalt, 2012 30.510.01.0