Tacrolimus (all routes)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5781
R14287		 Ichinose, 2018 Low birth weight (< 2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: Yes Co-exposure Mycophenolate: no 1.24 [0.17;9.24] -/15   -/39 - 15
ref
S12402
R46232		 Kim, 2015 Low birth weight (< 2.5 kg) throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No Co-exposure Mycophenolate: no 2.25 [0.87;5.82] C 12/28   15/60 27 28
ref
Total 2 studies 2.02 [0.86;4.75] 27 43
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ichinose, 2018Ichinose, 2018 1.24[0.17; 9.24]-1518%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Kim, 2015Kim, 2015 2.25[0.87; 5.82]272882%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.02[0.86; 4.75]27430.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.02[0.86; 4.75]27430%NAIchinose, 2018 Kim, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.24[0.17; 9.14]-15 -NAIchinose, 2018 1 exposed to other treatment, sickexposed to other treatment, sick 2.25[0.87; 5.82]2728 -NAKim, 2015 1 Tags Adjustment   - No  - No 2.25[0.87; 5.82]2728 -NAKim, 2015 1   - Yes  - Yes 1.24[0.17; 9.14]-15 -NAIchinose, 2018 1 Co-exposure Mycophenolate   - no  - no 2.02[0.86; 4.75]27430%NAIchinose, 2018 Kim, 2015 2 All studiesAll studies 2.02[0.86; 4.75]27430%NAIchinose, 2018 Kim, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.24[0.17; 9.14]-15 -NAIchinose, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.25[0.87; 5.82]2728 -NAKim, 2015 10.510.01.0