Tenofovir (local routes)

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5445
R14024		 Sibeko (vaginal gel), 2011 Early neonatal deaths (NOS) early pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Control group: Unexposed, sick Exposed group: TDF (only) Indication: HIV 0.18 [0.01;3.75] C 0/16   3/23 3 16
ref
Total 1 studies 0.18 [0.01;3.75] 3 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sibeko (vaginal gel), 2011Sibeko, 2011 1 0.18[0.01; 3.75]3160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: vaginal gel;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 Type of controls unexposed, sickunexposed, sick 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 Tags Adjustment   - Randomisation  - Randomisation 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 Control group   - Unexposed, sick  - Unexposed, sick 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 Exposed group   - TDF (only)  - TDF (only) 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 Indication   - HIV  - HIV 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 1 All studiesAll studies 0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.18[0.01; 3.75]316 -NASibeko (vaginal gel), 2011 10.510.01.0