Fluvoxamine updated on 07-01-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6247
R16563		 Malm, 2011 Ventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.42 [0.06;3.00] 1/240   5,465/628,607 5,466 240
ref
Total 1 studies 0.42 [0.06;2.97] 5,466 240
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Malm, 2011Malm, 2011 0.42[0.06; 3.00]5,4662400%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.42[0.06; 2.97]5,466240 -NAMalm, 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.42[0.06; 2.97]5,466240 -NAMalm, 2011 1 Tags Adjustment   - Yes  - Yes 0.42[0.06; 2.97]5,466240 -NAMalm, 2011 1 Monotherapy   - no or not specified  - no or not specified 0.42[0.06; 2.97]5,466240 -NAMalm, 2011 1 All studiesAll studies 0.42[0.06; 2.97]5,466240 -NAMalm, 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.42[0.06; 2.97]5,466240 -NAMalm, 2011 10.510.01.0