Fluvoxamine updated on 07-01-2025

Child/Infant death (> 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7928
R23998		 Stephansson, 2013 Postneonatal death (death between 28-364 days among neonatal survivors) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.23 [0.45;22.99] C
excluded (exposition period) 		1/324   1,538/1,604,649 1,539 324
ref
S7224
R20601		 Colvin, 2012 Death before 1 year during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.89 [0.60;5.95] -/-   1,058/94,561 - -
ref
Total 1 studies 1.89 [0.60;5.95] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2012Colvin, 2012 1.89[0.60; 5.95]--0%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.89[0.60; 5.95]-- -NAColvin, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.89[0.60; 5.95]-- -NAColvin, 2012 1 Tags Adjustment   - No  - No 1.89[0.60; 5.95]-- -NAColvin, 2012 1 Monotherapy   - no or not specified  - no or not specified 1.89[0.60; 5.95]-- -NAColvin, 2012 1 All studiesAll studies 1.89[0.60; 5.95]-- -NAColvin, 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.89[0.60; 5.95]1,049- -NAColvin, 2012 10.510.01.0