Escitalopram updated on 07-01-2025

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7472
R22357		 Anderson, 2020 Hypospadias, 2nd or 3rd degree 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.71 [0.31;1.61] -/-   0/- - -
ref
S7353
R21558		 Wemakor, 2015 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.25 [0.27;5.78] C 2/11   3,039/20,113 3,041 11
ref
Total 2 studies 0.81 [0.39;1.66] 3,041 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.71[0.31; 1.61]--78%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.25[0.27; 5.78]3,0411122%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.81[0.39; 1.66]3,041110.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.81[0.39; 1.66]3,041110%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.81[0.39; 1.66]3,041110%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 1.25[0.27; 5.78]3,04111 -NAWemakor, 2015 1   - Yes  - Yes 0.71[0.31; 1.62]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.81[0.39; 1.66]3,041110%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 0.81[0.39; 1.66]3,041110%NAAnderson, 2020 Wemakor, 2015 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.39; 1.66]3,041110%NAAnderson, 2020 Wemakor, 2015 20.510.01.0