Escitalopram updated on 07-01-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7472
R22342		 Anderson, 2020 Any neural tube defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.28 [0.56;2.90] -/-   0/- - -
ref
S7353
R21578		 Wemakor, 2015 Neural tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.44 [0.18;11.34] C 1/10   1,321/18,395 1,322 10
ref
Total 2 studies 1.30 [0.61;2.79] 1,322 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.28[0.56; 2.90]--86%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.44[0.18; 11.34]1,3221014%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.30[0.61; 2.79]1,322100.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.30[0.61; 2.79]1,322100%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.30[0.61; 2.79]1,322100%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 1.44[0.18; 11.34]1,32210 -NAWemakor, 2015 1   - Yes  - Yes 1.28[0.56; 2.91]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.30[0.61; 2.79]1,322100%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.30[0.61; 2.79]1,322100%NAAnderson, 2020 Wemakor, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.30[0.61; 2.79]1,322100%NAAnderson, 2020 Wemakor, 2015 20.510.01.0