Escitalopram updated on 07-01-2025

Ear, face and neck anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7353
R21565		 Wemakor, 2015 Ear, face and neck 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.55 [0.32;20.13] C 1/10   745/17,819 746 10
ref
S5890
R14795		 Ban (Controls unexposed, disease free), 2014 Ear, face, and neck malformations 1st trimester retrospective cohort (claims database) unexposed, disease free Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.09 [0.13;33.69] C 0/933   83/325,294 83 933
ref
Total 2 studies 2.37 [0.45;12.47] 829 943
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 2.55[0.32; 20.13]7461064%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ban (Controls unexposed, disease free), 2014Ban, 2014 1 2.09[0.13; 33.69]8393336%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 2.37[0.45; 12.47]8299430.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.09[0.13; 33.69]83933 -NABan (Controls unexposed, disease free), 2014 1 case control studiescase control studies 2.55[0.32; 20.13]74610 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.37[0.45; 12.47]8299430%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 2 Tags Adjustment   - No  - No 2.37[0.45; 12.47]8299430%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.55[0.32; 20.13]74610 -NAWemakor, 2015 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.09[0.13; 33.69]83933 -NABan (Controls unexposed, disease free), 2014 1 All studiesAll studies 2.37[0.45; 12.47]8299430%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.37[0.45; 12.47]8299430%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 20.510.01.0