Escitalopram updated on 07-01-2025

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7353
R21580		 Wemakor, 2015 Digestive system anomalies 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.39 [0.30;6.42] C 2/11   2,737/19,811 2,739 11
ref
S5890
R14791		 Ban (Controls unexposed, disease free), 2014 Digestive system malformations 1st trimester retrospective cohort (claims database) unexposed, disease free Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.56 [0.03;8.91] C 0/933   313/325,294 313 933
ref
S6015
R15510		 Jimenez-Solem (Controls unexposed, NOS), 2012 Congenital malformations of the digestive system 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.93 [0.06;14.94] C
excluded (control group) 		0/293   1,545/843,797 1,545 293
ref
S6020
R15606		 Jimenez-Solem (Controls unexposed, sick), 2012 Congenital malformations of the digestive system 1st trimester population based cohort retrospective unexposed, sick Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.92 [0.04;22.57] C 0/293   1/806 1 293
ref
Total 3 studies 1.09 [0.32;3.75] 3,053 1,237
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 1.39[0.30; 6.42]2,7391165%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ban (Controls unexposed, disease free), 2014Ban, 2014 1 0.56[0.03; 8.91]31393320%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Jimenez-Solem (Controls unexposed, sick), 2012Jimenez-Solem, 2012 2 0.92[0.04; 22.57]129315%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical Total (3 studies) I2 = 0% 1.09[0.32; 3.75]3,0531,2370.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.69[0.08; 5.61]3141,2260%NABan (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, sick), 2012 2 case control studiescase control studies 1.39[0.30; 6.42]2,73911 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.12[0.29; 4.28]3,0529440%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 2 unexposed, sickunexposed, sick 0.92[0.04; 22.57]1293 -NAJimenez-Solem (Controls unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.09[0.32; 3.75]3,0531,2370%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, sick), 2012 3 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.39[0.30; 6.42]2,73911 -NAWemakor, 2015 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.69[0.08; 5.61]3141,2260%NABan (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, sick), 2012 2 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.92[0.04; 22.57]1293 -NAJimenez-Solem (Controls unexposed, sick), 2012 1 All studiesAll studies 1.09[0.32; 3.75]3,0531,2370%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, sick), 2012 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6015

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.32; 3.62]4,5971,2370%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 3 unexposed, sick controlsunexposed, sick controls 0.92[0.04; 22.57]1293 -NAJimenez-Solem (Controls unexposed, sick), 2012 10.510.01.0