Escitalopram updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7929
R23999		 Stephansson, 2013 Stillbirth (after 22 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.72 [0.34;1.51] C
excluded (exposition period) 		7/2,641   5,919/1,604,649 5,926 2,641
ref
S7223
R20600		 Colvin, 2012 Stillbirths during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.63 [0.09;4.51] -/-   612/94,561 - -
ref
S6190
R16313		 Klieger-Grossmann, 2012 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.50 [0.25;9.07] C 3/213   2/212 5 213
ref
Total 2 studies 1.01 [0.27;3.79] 5 213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2012Colvin, 2012 0.63[0.09; 4.51]--46%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Klieger-Grossmann, 2012Klieger-Grossmann, 2012 1.50[0.25; 9.07]521354%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.01[0.27; 3.79]52130.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.01[0.27; 3.79]52130%NAColvin, 2012 Klieger-Grossmann, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.01[0.27; 3.79]52130%NAColvin, 2012 Klieger-Grossmann, 2012 2 Tags Adjustment   - No  - No 1.01[0.27; 3.79]52130%NAColvin, 2012 Klieger-Grossmann, 2012 2 MatchedMatched 1.50[0.25; 9.07]5213 -NAKlieger-Grossmann, 2012 1 Monotherapy   - no or not specified  - no or not specified 0.63[0.09; 4.46]-- -NAColvin, 2012 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.50[0.25; 9.07]5213 -NAKlieger-Grossmann, 2012 1 All studiesAll studies 1.01[0.27; 3.79]52130%NAColvin, 2012 Klieger-Grossmann, 2012 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.01[0.27; 3.79]6082130%NAColvin, 2012 Klieger-Grossmann, 2012 20.510.01.0