Methotrexate (Pre-conception only) - Medication and Pregnancy KB

Methotrexate (Pre-conception only)

Minor congenital malformations

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S10348 R37941	Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014	Minor birth defects	preconceptional for kinetic reason	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched MTX less than 3 months before pregnancy	0.78 [0.29;2.10] ^C excluded (control group)	5/113 22/392	27	113		ref
S10349 R37960	Weber-Schoendorfer (Controls unexposed, disease free), 2014	Minor birth defects	preconceptional for kinetic reason	prospective cohort	unexposed, disease free	Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched MTX less than 3 months before pregnancy	1.96 [0.73;5.26] ^C	5/113 23/997	28	113		ref
					Total	1 studies	1.96 [0.73;5.26]		28	113
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, disease free;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10348