| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S6697 R18863 |
Svirsky, 2017 | Early missed abortion (< 12 weeks) | preconceptional for kinetic reason | retrospective cohort | unexposed, sick | Adjustment: No Exposed group: MTX (monotherapy) MTX more than 3 months before pregnancy MTX treatment for ectopic pregnancy | 0.17 [0.05;0.58] C | 3/93 22/133 | 25 | 93 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10348 R37934 |
Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 | Spontaneous abortion (fetus weighing <500 gm or <23 weeks of completed gestation) | preconceptional for kinetic reason | prospective cohort | exposed to other treatment, sick excluded | Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched MTX less than 3 months before pregnancy |
0.80 [0.40;1.40] excluded (control group) |
12/136 44/459 | 56 | 136 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10349 R37953 |
Weber-Schoendorfer (Controls unexposed, disease free), 2014 | Spontaneous abortion (fetus weighing <500 gm or <23 weeks of completed gestation) | preconceptional for kinetic reason | prospective cohort | unexposed, disease free | Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched MTX less than 3 months before pregnancy | 1.30 [0.60;3.00] | 12/136 79/1,107 | 91 | 136 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S7243 R21017 |
Svirsky, 2009 | Abortion (Early missed) | preconceptional for kinetic reason | retrospective cohort | unexposed, sick | Adjustment: No Exposed group: MTX (monotherapy) MTX more than 3 months before pregnancy MTX treatment for ectopic pregnancy | 0.62 [0.22;1.71] C | 6/45 16/80 | 22 | 45 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 0.55 [0.18;1.70] | 138 | 274 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, disease free;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 10348