Methotrexate (Pre-conception only)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7243
R21021		 Svirsky, 2009 Low-birth weight (NOS) preconceptional for kinetic reason retrospective cohort unexposed, sick Adjustment: No Exposed group: MTX (monotherapy) MTX more than 3 months before pregnancy MTX treatment for ectopic pregnancy 0.81 [0.27;2.37] C 6/37   12/62 18 37
ref
Total 1 studies 0.81 [0.27;2.37] 18 37
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Svirsky, 2009Svirsky, 2009 0.81[0.27; 2.37]18370%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 Tags Adjustment   - No  - No 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 Exposed group   - MTX (monotherapy)  - MTX (monotherapy) 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 MTX more than 3 months before pregnancyMTX more than 3 months before pregnancy 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 MTX treatment for ectopic pregnancyMTX treatment for ectopic pregnancy 0.81[0.27; 2.37]1837 -NASvirsky, 2009 1 All studiesAll studies 0.81[0.27; 2.37]1837 -NASvirsky, 2009 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.81[0.27; 2.37]1837 -NASvirsky, 2009 10.510.01.0