Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13740
R53538		 Reynolds, 2022 Pre-eclampsia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indications: Systemic lupus erythematosus (SLE) 1.53 [0.68;3.43] C 11/82   17/185 28 82
ref
S12244
R53502		 Kanis, 2021 Hypertension/pre-eclampsia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 1.10 [0.56;2.16] C 13/240   28/564 41 240
ref
S10792
R52292		 Casanova, 2013 Preeclampsy 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort exposed to other treatment, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 0.57 [0.02;13.96] C
excluded (exposition period) 		0/187   1/318 1 187
ref
Total 2 studies 1.26 [0.75;2.11] 69 322
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reynolds, 2022Reynolds, 2022 1.53[0.68; 3.43]288241%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Kanis, 2021Kanis, 2021 1.10[0.56; 2.16]4124059%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.26[0.75; 2.11]693220.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.26[0.75; 2.11]693220%NAReynolds, 2022 Kanis, 2021 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.26[0.75; 2.11]693220%NAReynolds, 2022 Kanis, 2021 2 Tags Adjustment   - No  - No 1.26[0.75; 2.11]693220%NAReynolds, 2022 Kanis, 2021 2 Indications   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 1.10[0.56; 2.16]41240 -NAKanis, 2021 1   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.53[0.68; 3.43]2882 -NAReynolds, 2022 1 All studiesAll studies 1.26[0.75; 2.11]693220%NAReynolds, 2022 Kanis, 2021 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.26[0.75; 2.11]693220%NAReynolds, 2022 Kanis, 2021 20.510.01.0