Thiopurines (Azathioprine, Mercaptopurin) - Medication and Pregnancy KB

Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Cardiac septal defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S6258 R18170	Cleary (Controls unexposed, NOS), 2009	Ventricular/Atrial septal defects	early pregnancy	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Indications: Any or not specified	3.18 [1.45;6.04] excluded (control group)	9/481 6,629/1,181,450	6,638	481		ref
S12174 R45436	Cleary (Controls unexposed, sick), 2009	Ventricular/Atrial septal defects	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes Indications: Any or not specified	1.91 [0.75;4.57]	9/481 17/1,739	26	481		ref
					Total	1 studies	1.91 [0.77;4.71]		26	481
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6258