Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6698
R52662		 Alami, 2017 Ectopic pregnancy at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 3.02 [0.12;74.97] C 1/124   0/124 1 124
ref
S11066
R45551		 Francella, 2003 Ectopic pregnancy throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 3.00 [0.12;77.09] C 0/15   1/132 1 15
ref
S13739
R53530		 Tennenbaum, 1999 Ectopic pregnancy during pregnancy (anytime or not specified) excluded retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 4.64 [0.27;79.95] C
excluded (exposition period) 		1/12   1/52 2 12
ref
Total 2 studies 3.01 [0.31;29.53] 2 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Alami, 2017Alami, 2017 3.02[0.12; 74.97]112451%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Francella, 2003Francella, 2003 3.00[0.12; 77.09]11549%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 3.01[0.31; 29.53]21390.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.01[0.31; 29.53]21390%NAAlami, 2017 Francella, 2003 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.01[0.31; 29.53]21390%NAAlami, 2017 Francella, 2003 2 Tags Adjustment   - No  - No 3.01[0.31; 29.53]21390%NAAlami, 2017 Francella, 2003 2 Indications   - Any or not specified  - Any or not specified 3.02[0.12; 74.97]1124 -NAAlami, 2017 1   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 3.00[0.12; 77.09]115 -NAFrancella, 2003 1 All studiesAll studies 3.01[0.31; 29.53]21390%NAAlami, 2017 Francella, 2003 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.01[0.31; 29.53]21390%NAAlami, 2017 Francella, 2003 20.510.01.0