Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Hearing loss / Auditory deficit

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7056
R52640		 Marder, 2013 Hearing impairment - At age < 2 years during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications: Systemic lupus erythematosus (SLE) 12.13 [0.46;317.61] C 1/13   0/47 1 13
ref
Total 1 studies 12.13 [0.46;317.61] 1 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marder, 2013Marder, 2013 12.13[0.46; 317.61]1130%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.13[0.46; 317.61]113 -NAMarder, 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 12.13[0.46; 317.61]113 -NAMarder, 2013 1 Tags Adjustment   - No  - No 12.13[0.46; 317.61]113 -NAMarder, 2013 1 Indications   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 12.13[0.46; 317.61]113 -NAMarder, 2013 1 All studiesAll studies 12.13[0.46; 317.61]113 -NAMarder, 2013 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale12.13[0.46; 317.61]113 -NAMarder, 2013 10.510.01.0